September 15, 2022
Illustration of Receptor Occupancy (RO) in a cell | Precision for Medicine

Advancing Clinical Development of Immuno-modulatory Therapies with Flow Cytometry-Based Receptor Occupancy Assays

  The emergence of immuno-modulatory therapies has sparked increased interest in measuring cell-based receptor engagement and modulation in patients who have been treated with these novel medicines. Measuring receptor occupancy (RO) can be challenging and developing reproducible RO assays that can be used in clinical trials requires careful planning.   […]
August 23, 2022
DNA Strand

Monitoring Immune Responses in Gene Therapy Clinical Trials Using ELISpot

Gene Therapy and Cellular Immunity With two approved products currently on the market and a growing pipeline, adeno-associated virus (AAV)-based gene therapies have emerged as promising modalities for treating an array of hereditary diseases. AAV vectors offer several advantages as gene therapy vehicles, including high transduction efficiency, less immunogenicity than […]
August 15, 2022

Solving the Unique Central Lab Services Challenges of Precision Medicine Trials

Solving the Unique Central Lab Services Challenges of Precision Medicine Trials Drug development requires significant investment, not just in dollars, but also in effort and expertise. In today’s precision medicine landscape, where biomarker-driven clinical trials and studies with complex designs are becoming more common, it is increasingly difficult to coordinate […]
August 4, 2022
Epigenetic Immunophenotyping for treatment of Hepatocellular Carcinoma

Using Epigenetic Immunophenotyping to Explore Potential Biomarkers for Predicting Response to Immunotherapy-Based Combination Treatment in Hepatocellular Carcinoma

The development of immunotherapy with checkpoint inhibitors in the last decade was a key breakthrough in the treatment of patients with various types of cancer. The efficacy of checkpoint inhibitors has been demonstrated for disseminated melanoma, renal cell carcinoma and non small cell lung cancer, suggesting that these therapeutics are […]
July 22, 2022
Antibody proteins attack a corona virus pathogen cell - 3d illustration

Using Non-Invasive Immune Monitoring for Predicting COVID-19 Disease Course and Assessing SARS-CoV-2 Vaccine Response

Since the beginning of the SARS-CoV-2 pandemic, a key focus of research has been characterizing the human immune response in relation to the virus. Understanding how immune cell profiles change during acute infection or in response to vaccination may be key to predicting disease course or vaccine efficacy. Over the […]
June 16, 2022
laboratory work - translational medicine

Strategies to Support Successful Translation of Preclinical Biomarker Assays

Precision medicine focuses on delivering personalized approaches to matching the right patient with the right drug at the right dose and time to optimize treatment impact and patient outcome. Progress in precision medicine has been driven by advances in technology that enable identification of mutations and characterization of molecular targets. […]
January 26, 2022
mIF analysis of hot vs. cold tumors

Assessing the Tumor Microenvironment to Optimize Clinical Trial Success: Spatial Analysis with Multiplex Immunofluorescence

Knowledge of the tumor microenvironment must be incorporated into clinical trials to increase the overall success rate of investigative oncology drugs. Understanding the phenotypes and spatial arrangement of cells present in the tumor microenvironment will help developers to better guide therapy and better predict outcomes, and multiplex IF is one important way to gather this information.
February 5, 2022

The Significance of Genomics Analysis in Gene Therapy Development

Gene therapy development is a complex undertaking that requires multiple checks to ensure safety and efficacy. Genomics analysis has become a valuable tool for providing insight such as characterizing viral vectors, targeting to the correct tissue, likelihood of shedding, and on-/off- target binding. With this data, clinical developers can make informed decisions about their therapeutic candidates.
March 17, 2021
Etigilimab decreases Treg frequency

Next Generation Immune Monitoring in Immuno-oncology Trials

A critical component of I-O studies, immune monitoring is essential for understanding, predicting, and monitoring the immune system response to therapeutic interventions. Epiontis ID is a next generation method of immune monitoring based on measuring cell type-specific epigenetic markers that identify uniquely demethylated regions on genomic DNA. Learn more, and view the on demand webinar.