January 13, 2023
Multiplex immunofluorescent IHC (mIF) in Immuno-Oncology and Dermatology

Maximizing the Scientific Value of Tissue Biomarker Analysis: Case Studies in Immuno-Oncology and Dermatology

  Complex diseases and target organ structures often require detailed interrogation of tissue to provide insight into disease biology or to investigate drug efficacy and safety. While tissue biopsies can be invasive, they do enable localized analysis of protein biomarkers and topographic investigation of disease-and drug-related changes. Over recent years, […]
December 13, 2022

Characterizing a Central Switch of Immune Suppression: Monitoring Treg Cells in Clinical Studies

Regulatory T (Treg) cells play a critical role in suppressing the immune response, thereby maintaining immune homeostasis and self-tolerance. Dysregulation in Treg cell type, frequency, or function is implicated in a variety of conditions, including autoimmune disease and cancer. There is still much to learn about Treg effector functions and […]
November 8, 2022
Microscope Slide (Stained)

Developing an Immunohistochemistry Assay for Human Spermine Oxidase to Evaluate Human Cancer Tissues

Polyamines (PAs) are involved in numerous cellular functions, including cell growth, proliferation, migration, gene regulation, and maintenance of cellular oxidative homeostasis1. Deregulation of PA metabolism has been associated with the various epithelial cancers and neurodegenerative diseases. Alterations in PA metabolism may cause cellular damage and apoptosis through the generation of oxidative […]
September 15, 2022
Illustration of Receptor Occupancy (RO) in a cell | Precision for Medicine

Advancing Clinical Development of Immuno-modulatory Therapies with Flow Cytometry-Based Receptor Occupancy Assays

  The emergence of immuno-modulatory therapies has sparked increased interest in measuring cell-based receptor engagement and modulation in patients who have been treated with these novel medicines. Measuring receptor occupancy (RO) can be challenging and developing reproducible RO assays that can be used in clinical trials requires careful planning.   […]
August 23, 2022
DNA Strand

Monitoring Immune Responses in Gene Therapy Clinical Trials Using ELISpot

Gene Therapy and Cellular Immunity With two approved products currently on the market and a growing pipeline, adeno-associated virus (AAV)-based gene therapies have emerged as promising modalities for treating an array of hereditary diseases. AAV vectors offer several advantages as gene therapy vehicles, including high transduction efficiency, less immunogenicity than […]
August 15, 2022

Solving the Unique Central Lab Services Challenges of Precision Medicine Trials

Solving the Unique Central Lab Services Challenges of Precision Medicine Trials Drug development requires significant investment, not just in dollars, but also in effort and expertise. In today’s precision medicine landscape, where biomarker-driven clinical trials and studies with complex designs are becoming more common, it is increasingly difficult to coordinate […]
August 4, 2022
Epigenetic Immunophenotyping for treatment of Hepatocellular Carcinoma

Using Epigenetic Immunophenotyping to Explore Potential Biomarkers for Predicting Response to Immunotherapy-Based Combination Treatment in Hepatocellular Carcinoma

The development of immunotherapy with checkpoint inhibitors in the last decade was a key breakthrough in the treatment of patients with various types of cancer. The efficacy of checkpoint inhibitors has been demonstrated for disseminated melanoma, renal cell carcinoma and non small cell lung cancer, suggesting that these therapeutics are […]
July 22, 2022
Antibody proteins attack a corona virus pathogen cell - 3d illustration

Using Non-Invasive Immune Monitoring for Predicting COVID-19 Disease Course and Assessing SARS-CoV-2 Vaccine Response

Since the beginning of the SARS-CoV-2 pandemic, a key focus of research has been characterizing the human immune response in relation to the virus. Understanding how immune cell profiles change during acute infection or in response to vaccination may be key to predicting disease course or vaccine efficacy. Over the […]
June 16, 2022
laboratory work - translational medicine

Strategies to Support Successful Translation of Preclinical Biomarker Assays

Precision medicine focuses on delivering personalized approaches to matching the right patient with the right drug at the right dose and time to optimize treatment impact and patient outcome. Progress in precision medicine has been driven by advances in technology that enable identification of mutations and characterization of molecular targets. […]