January 26, 2022
mIF analysis of hot vs. cold tumors

Assessing the Tumor Microenvironment to Optimize Clinical Trial Success: Spatial Analysis with Multiplex Immunofluorescence

Knowledge of the tumor microenvironment must be incorporated into clinical trials to increase the overall success rate of investigative oncology drugs. Understanding the phenotypes and spatial arrangement of cells present in the tumor microenvironment will help developers to better guide therapy and better predict outcomes, and multiplex IF is one important way to gather this information.
February 5, 2022

The Significance of Genomics Analysis in Gene Therapy Development

Gene therapy development is a complex undertaking that requires multiple checks to ensure safety and efficacy. Genomics analysis has become a valuable tool for providing insight such as characterizing viral vectors, targeting to the correct tissue, likelihood of shedding, and on-/off- target binding. With this data, clinical developers can make informed decisions about their therapeutic candidates.
March 17, 2021
Etigilimab decreases Treg frequency

Next Generation Immune Monitoring in Immuno-oncology Trials

A critical component of I-O studies, immune monitoring is essential for understanding, predicting, and monitoring the immune system response to therapeutic interventions. Epiontis ID is a next generation method of immune monitoring based on measuring cell type-specific epigenetic markers that identify uniquely demethylated regions on genomic DNA. Learn more, and view the on demand webinar.
February 4, 2021

Taking a Holistic Approach to Sample Management and Sample Processing for Your Clinical Trial

Patient samples have always been critical assets for clinical trial success. In this era of precision medicine, in which researchers seek to tailor treatments on the basis of a specific patient’s biomarker profile or disease characteristics, sample management has become even more important and valuable. It is critical to ensure that clinical samples collected during a trial constitute a robust sample set that can be used for elucidating mechanism of action, stratifying patients, and monitoring response to treatment. Consequently, having a plan to ensure sample quality, minimize processing time post-blood draw, and manage logistics is crucial for optimizing the accuracy and integrity of clinical trial data.
February 4, 2021

Choosing the Right Partner: Special Sample Needs For In Vitro Diagnostics

Is a sample just a sample? You’d be surprised. Karen Richards, vice president, In Vitro Diagnostics and Quality, discusses the importance of sample collection and many of the sample source and trial design challenges facing in vitro diagnostics innovator.