Clinical Application: Pharmacodynamic Assessment of a CK2 Inhibitor Key Words: PBMCs, CTCs, plasma, biomarker expression, pharmacodynamics Background: CK2 protein kinase is a constitutively active enzyme that mediates signaling in multiple pathways including oncogene and cytokine signaling. CK2 is an attractive target for anticancer therapy due to its overexpression in most […]

Clinical Application: Identification of folate receptor alpha (FRA) positive CTCs for patient stratification Key Words: CTCs, ApoStream®, patient stratification, protein expression, NSCLC Background: This study was initiated to explore the utility of using biomarker expression levels in CTCs as a means of patient selection for treatment in a clinical trial. […]

Clinical Application: Pharmacodynamic analysis of a DNA damaging agent to identify a predictive signature for clinical response Key Words: CTCs, ApoStream®, pharmacodynamics, DNA damage, protein expression, LSC, breast cancer Background: Topoisomerase 1 is a nuclear enzyme that plays an essential role in DNA replication, transcription, recombination, and repair. It is […]