Global Immune
Monitoring Services and Solutions
Precision provides an industry-leading array of comprehensive immune monitoring services and solutions, from the development of customized assays for early clinical studies to managing the logistical and immune monitoring testing needs of global, multi-site studies.
We leverage multiple technology platforms on a global scale, including proprietary innovations like Epiontis ID®, which provides immunophenotyping even on non-viable samples. Our expertise also extends to analyzing immune status of tumor or tissue biopsies, and liquid biopsy analysis of rare circulating tumor cells.
Immune Monitoring by Flow Cytometry
Flow cytometry provides high-dimensional insight into immune cells and target engagement. We have both research-grade instruments for up to 20 parameters analysis, and CLIA instruments, all supported by a global sample processing and logistics network to ensure sample integrity.
Immune Monitoring by Epiontis ID
Precision’s proprietary Epiontis ID technology delivers robust, repeatable, yet cost-effective immune cell phenotyping without the need for viable cells. With over 100,000 clinical samples analyzed, Epiontis ID is a globally-accepted immune monitoring technology.
Cytokine Profiling
For an in-depth assessment of inflammatory responses, our cytokine profiling assays are designed to measure cytokines and chemokines released from chosen target cells. We use Luminex, MesoScale Discovery, and Quanterix SIMOA technology for sensitive detection in complex matrices, as well as ELISAs for single analytes.
Gene Expression Profiling of Biopsies
Understand target expression, adaptive and innate immune responses at the gene expression level. Technologies we use for gene expression profiling include NanoString, Illumina RNA-seq, ddPCR, and qPCR.
ELISpot and FluoroSpot
ELISpot and FluoroSpot can quantify antigen-specific T or B cells. Both ELISpot and FluoroSpot assays are offered to support global preclinical and clinical projects, providing pre-validation and validation services using standard and custom assays.
In addition to assays, we offer large banks of cryopreserved control cells.
Custom Immune Monitoring Assays
For custom assays, we apply our scientific expertise and engineering excellence to design effective and efficient assays to achieve your project’s specific goals.
Learn about the technology behind Epiontis ID:
Created in collaboration with Nature, the Epiontis Poster illustrates the numerous cellular pathways involved in autoimmune disorders and their current therapies:
Learn more about our Immune Monitoring Solutions
To flow or not to flow: immune cell profiling in translational research
Learn about the immune monitoring strengths of both flow cytometry and epigenetic immune profiling, including when each of these technologies can best be utilized in a clinical study.
Efficient sample management logistics enable global immune monitoring services
Precision’s immune monitoring services are strengthened by a global logistics network, designed to safeguard sample integrity and maximize data reliability.
Global sample processing
- Global PBMC processing in 24-hours or less
- Regular competency assessment and monitoring to ensure site-to-site and lab-to-lab data comparability
- Long- and short-term storage at optimal temperatures
Controlled biostorage
Our 100,000 sq. ft. primary biorepository was the first to receive CAP certification and currently stores >20 million biospecimens under controlled conditions. We can store any type of fluid or solid biological specimen at controlled ambient temperatures, +4℃, -20℃, -80℃, or in liquid nitrogen vapor.
The biorepository includes numerous security and safety features:
- Redundant back-up systems, dedicated back-up units
- Around-the-clock automated temperature monitoring
- In-house HVAC technicians, specializing in cascade refrigeration
Additional specialty lab services
Tissue & Liquid Biopsy
Precision offers a range of complex solutions to analyze tissue and liquid biopsies, including quantitative multiplex immunofluorescence, and our proprietary ApoStream platform which can isolate and enrich circulating tumor cells for downstream analysis.
Bioanalytical Testing
We provide bioanalytical support for biologics, cell therapies, gene therapies, and offer companion diagnostics development services. Our bioanalytical group is recognized for their leadership in immunogenicity testing.
Biospecimens
We stock a range of cryopreserved cells, all of which are ready for immediate domestic and international delivery through our network of distributors. Additionally, we offer prospective collections for any study need.
