March 24, 2021

Pharmacodynamic Analysis of DNA Damage Biomarkers in CTCs as Part of the Phase III BEACON Trial in Breast Cancer

Clinical Application: Pharmacodynamic analysis of a DNA damaging agent to identify a predictive signature for clinical response Key Words: CTCs, ApoStream®, pharmacodynamics, DNA damage, protein expression, LSC, breast cancer Background: Topoisomerase 1 is a nuclear enzyme that plays an essential role in DNA replication, transcription, recombination, and repair. It is […]
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March 24, 2021

Optimization of CTC Recovery Methods and Biomarker Analysis in Hepatocellular Carcinoma Patients

Clinical Application: pharmacodynamic analysis of compound therapy in hepatocellular carcinoma (HCC) patients Key Words: CTCs, protein expression, pharmacodynamics, head-to-head comparison, ApoStreamTM, HCC Background: Hepatocellular carcinoma (HCC) is a rare cancer type in the United States; a large number of HCC cases are from distant metastases arising from other cancers, indicating […]
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Precision for Medicine is part of the Precision Medicine Group, an integrated team of experts that extends Precision for Medicine’s therapeutic development capabilities beyond approval and into launch strategies, marketing communication, and payer insights. As one company, the Precision Medicine Group helps pharmaceutical and life-sciences clients conquer product development and commercialization challenges in a rapidly evolving environment.

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