March 24, 2021

Pharmacodynamic Analysis of DNA Damage Biomarkers in CTCs as Part of the Phase III BEACON Trial in Breast Cancer

Clinical Application: Pharmacodynamic analysis of a DNA damaging agent to identify a predictive signature for clinical response Key Words: CTCs, ApoStream®, pharmacodynamics, DNA damage, protein expression, LSC, breast cancer Background: Topoisomerase 1 is a nuclear enzyme that plays an essential role in DNA replication, transcription, recombination, and repair. It is […]
March 24, 2021

Characterization of Specific EGFR Mutations in CTCs Isolated by ApoStream® in NSCLC Patients

March 24, 2021

Optimization of CTC Recovery Methods and Biomarker Analysis in Hepatocellular Carcinoma Patients

Clinical Application: pharmacodynamic analysis of compound therapy in hepatocellular carcinoma (HCC) patients Key Words: CTCs, protein expression, pharmacodynamics, head-to-head comparison, ApoStreamTM, HCC Background: Hepatocellular carcinoma (HCC) is a rare cancer type in the United States; a large number of HCC cases are from distant metastases arising from other cancers, indicating […]