Gene Expression Profiling of Biopsies

Gene expression profiling of tumor biopsies and liquid biopsies can provide insight into inflammation and overall immune status. Profiling of biopsies by gene expression can serve as a tool for screening tumors that may respond to treatments such as checkpoints inhibitors, for evaluating therapeutic efficacy, for illuminating mechanism of action, and for a range of other applications.

Precision offers gene expression profiling and transcriptomics assays to monitor immune status using next generation sequencing (NGS), Nanostring, qPCR, and digital droplet PCR (ddPCR) technologies.

For sample types and needs other than immune profiling of biopsies, Precision also offers a full suite of genomics applications.

Gene Expression Profiling of Biopsies

Gene expression profiling of tumor biopsies and liquid biopsies can provide insight into inflammation and overall immune status. Profiling of biopsies by gene expression can serve as a tool for screening tumors that may respond to treatments such as checkpoints inhibitors, for evaluating therapeutic efficacy, for illuminating mechanism of action, and for a range of other applications.

Precision offers gene expression profiling and transcriptomics assays to monitor immune status using next generation sequencing (NGS), Nanostring, qPCR, and digital droplet PCR (ddPCR) technologies.

For sample types and needs other than immune profiling of biopsies, Precision also offers a full suite of genomics applications.

Comprehensive and quantitative gene expression profiling

Our services are designed to meet your project objectives, whether through pre-existing panels or a customized assay.
Illumina NGS sequencers

We use the Illumina platform for RNA-seq studies, including the AmpliSeq for Illumina Immune Response Panel.

Learn more about our NGS capabilities >

Nanostring nCounter®

For highly multiplexed, quantitative gene expression studies, we use the Nanostring nCounter® platform. This system directly detects RNA, avoiding the potential for introduced bias with approaches that rely on PCR-based amplification.

We can use Nanostring’s immuno-oncology and immunology panels or create a custom panel for your study.

Learn more about our Nanostring capabilities >

QuantStudio™ 12K flex real-time PCR system

For cost-effective, multiplexed gene expression profiling of many samples in parallel, we offer analyses using OpenArray(™) plates on the QuantStudio 12K Flex qPCR platform.

Learn more about our qPCR capabilities >

QX200™ ddPCR™

Digital PCR is appropriate when highly sensitive analyses and absolute quantification is needed. Precision utilizes the Bio-Rad QX200 ddPCR System.

Learn more about our ddPCR capabilities >

Integrating biomarker and clinical trial data

To help researchers understand and interpret biomarker assay data in the context of other assays as well as the clinical trial data, Precision provides the option of managing and analyzing data using our proprietary QuartzBio Translational Informatics platform.

Learn more about the computational biology, informatics, and sample inventory management capabilities of QuartzBio >

Global reach, multi-site support

Our gene expression profiling services support pre-clinical and clinical research, including multi-site studies, conducted anywhere in the world.

Working with Precision

Precision’s specialty lab scientists take a collaborative and consultative approach to projects and can provide recommendations on biomarker assay strategies and implementation. Services can be provided individually or as part of a comprehensive therapeutic development package including biomarker assays and clinical trials.

Related services

Immune Monitoring by Flow Cytometry

Flow cytometry provides high-dimensional insight into immune cells and target engagement. We have both research-grade instruments for up to 20 parameters analysis, and CLIA instruments, all supported by a global sample processing and logistics network to ensure sample integrity.

Immune Monitoring by Epiontis ID

Precision’s proprietary Epiontis ID technology delivers robust, repeatable, yet cost-effective immune cell phenotyping without the need for viable cells. With over 100,000 clinical samples analyzed, Epiontis ID is a globally-accepted immune monitoring technology.

Cytokine Profiling

For an in-depth assessment of inflammatory responses, our cytokine profiling assays are designed to measure cytokines and chemokines released from chosen target cells. We use Luminex, MesoScale Discovery, and Quanterix SIMOA technology for sensitive detection in complex matrices, as well as ELISAs for single analytes.

Discuss your project requirements

Whether you know exactly the type of immune monitoring approach you need or would like expert support with project design, we can deliver.

Discuss your project requirements

Whether you know exactly the type of immune monitoring approach you need or would like expert support with project design, we can deliver.

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