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Meso Scale Discovery (MSD) Assays

Profile cytokines, detect biomarkers, or perform ADA & PK studies at any clinical phase with MSD

Understanding the abundance of a specific protein or set of proteins is one of the most basic measurements needed in pre-clinical and clinical research. The Meso Scale Discovery (MSD) platform can analyze these with consistency, high-throughput, and low sample input.

Precision can help you develop and validate custom MSD panels, or run fully validated kits.

MSD capabilities
Regulatory expertise
MSD assay formats
Validated MSD kits
Instruments
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What is Meso Scale Discovery?

The MSD technology is a method that works on the same principle as ELISA assays but relies on eletrochemiluminescent (ECL) signals as a detection method.

This gives MSD platform several advantages over traditional ELISA:

  • Flexible multiplexing: up to 10 analytes
  • Wider dynamic range
  • Higher sensitivity
  • Lower sample volume
  • Less matrix interference
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How Precision uses MSD to empower your research

For non-clinical and clinical studies, perform:

  • Biomarker and cytokine profiling
  • Pharmacokinetic (PK) and anti-drug antibody (ADA) assays
  • Or develop PK and ADA assays de novo by conjugating capture and detection antibodies with biotin or Sulfo-tag

With our MSD expertise, navigate and plan for:

  • Challenges of multiplexing, reagent procurement, data tabulation, matrix interference, and bridging of reagents

Strategize with us to:

  • Choose which biomarkers to target, ideal platform, and level of regulation
  • Develop methods or optimize existing protocols for your specific requirements to accelerate your clinical program

Precision employs a platform-agnostic approach in working with you to choose the best solution, whether that be MSD, ELISA, or another format.

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Support your assays with comprehensive regulatory expertise

  • Assay development or transfer, qualification, validation, and non-clinical and clinical sample testing
  • Pre-built, validated MSD assay plates
  • Support pre-clinical through phase 3 and post marketing studies
  • GCP/GLP/CLIA/CDx regulated assays

Assays to address any of your endpoints

R-PlexU-PlexT-PlexV-PlexS-Plex

Matched antibody sets for your own single or multiplex assay

Flexible, customized multiplex assays

Ready-to-use single and multiplex assays kits

Validated single and multiplex assay kits

Ultrasensitive single plex and multiplex assay kits

Provides an expanding menu of emerging biomarkers with MSD MULTI-ARRAY performance

Easily creates customized multiplex panels. Use MSD reagents or bring your own

Analyzes protein levels from many sample types with a single assay. Improved analytical performance

Provides confidence and reliability. Analytically validated with guaranteed performance specifications

Measures proteins that are otherwise unmeasurable.

Explore some validated kits and the markers they measure

V-PLEX Cytokine Panel 1 Human Kit

GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A

V-PLEX Proinflammatory Panel 1 Human Kit

IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α

V-PLEX Chemokine Panel 1 Human Kit

MCP-1, MCP-4, Eotaxin, Eotaxin-3, IP-10, MDC, TARC, MIP-1α, MIP-1β, IL-8 (HA), IL-8

 

Precision's available MSD instruments

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Meso Sector S 600MM

High speed, low-noise CCD camera; high sensitivity, wide dynamic range, rapid read times

Meso Quickplex SQ 120MM

Multi-array technology combines high sensitivity, excellent reproducibility and wide dynamic range. 

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