Target Validation, Biomarker Validation, and Safety

Effectively identifying and validating therapeutic targets and biomarkers are key to effective precision therapeutic development. Precision for Medicine provides a range of human tissue-based research services from the preclinical to clinical stages of development.

We specialize in utilizing these services for small molecule, large molecule, and advanced therapeutics (gene and cell therapies) to help you understand target expression and localization, determine tumor biology and cellular interplay, and characterize novel therapeutic entities.

Target Validation, Biomarker Validation, and Safety

Effectively identifying and validating therapeutic targets and biomarkers are key to effective precision therapeutic development. Precision for Medicine provides a range of human tissue-based research services from the preclinical to clinical stages of development.

We specialize in utilizing these services for small molecule, large molecule, and advanced therapeutics (gene and cell therapies) to help you understand target expression and localization, determine tumor biology and cellular interplay, and characterize novel therapeutic entities.

Precision’s technologies providing biomarker and safety insights

Whole Body Target Expression Platform

Whole body target expression data enable target validation, opportunity for drug repurposing, evaluation of potential clinical safety concerns, and validation of animal models, using our proprietary qRT-PCR-based platform.

Cell Based Assays & Cell Based Imaging

Develop and qualify 2D and 3D human in vitro cell-based models using a broad range of human primary cell types. Our broad array of analytical platforms enables a variety of assay endpoints, including cytokine release, apoptosis, gene expression cell migration, immunocytochemistry, and high content cellular imaging.

Tissue Cross-Reactivity (TCR)

Screen biotherapeutics for tissue cross-reactivity (TCR) using tissue microarrays or obtain full GLP TCR data to support IND filing with Precision’s biospecimens and IHC-based TCR testing services.

Fluorescence In Situ Hybridization (FISH)/ISH

Detect chromosomal abnormalities and profile gene expression in tissue or liquid biopsies using our multiplex FISH/ISH services. FISH/ISH can be integrated with other technologies to add spatial context and generate multidimensional data sets.

Multiplex Immunofluorescence

We offer automated multiplex immunofluorescence (mIF) services that enable quantitative visualization of up to 9 markers in tissue and liquid biopsies, and individual cells. mIF can be integrated with other methods, including co-analysis using fluorescent in situ hybridization/in situ hybridization (FISH/ISH).

Immunohistochemistry (IHC)

Precision’s immunohistochemistry (IHC) services can be customized based on study needs, and can include development of logistical processes, kitting, special stains, and creation of a custom assay and scoring system.

Experimental Design, Execution, Data Interpretation, and Reporting

Precision’s target and biomarker validation and safety services include consultative study design and assay development, analysis and interpretation of data, and data reporting, which can be delivered via our proprietary data and biomarker tool, QuartzBio.

Additional Specialty Lab Services

Tissue & Liquid Biopsy

Obtain a detailed molecular view into patient biology with a range of tissue and liquid biopsy technologies, including our proprietary ApoStream platform, which can isolate and enrich circulating tumor cells for downstream analysis.

Bioanalytical Testing

Get bioanalytical support for your biologic, cell therapy, gene therapy, or companion diagnostics program from the globally-recognized leaders in immunogenicity testing.

Immune Monitoring

Leverage sophisticated multiplex flow cytometry approaches and other technologies, including our proprietary Epiontis ID platform, to characterize the immune cells in your samples and understand their impact on disease and patient biology.

Discover how our target and biomarker validation services can advance your pre-clinical or clinical development program

Discover how our target and biomarker validation services can advance your pre-clinical or clinical development program

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