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Profilage de l'expression génétique des biopsies

Le profilage des biopsies par l'expression des gènes peut servir d'outil pour le dépistage des tumeurs susceptibles de répondre à des traitements tels que les inhibiteurs de points de contrôle, pour l'évaluation de l'efficacité thérapeutique, pour la mise en évidence du mécanisme d'action et pour toute une série d'autres applications.
Le profilage de l'expression génétique des biopsies tumorales et des biopsies liquides peut fournir des informations sur l'inflammation et l'état immunitaire général.

Profilage complet et quantitatif de l'expression des gènes

Precision propose des tests de profilage de l'expression génique et de transcriptomique pour surveiller l'état immunitaire à l'aide des technologies de séquençage de nouvelle génération (NGS), NanoString, qPCR et Droplet Digital™ PCR (ddPCR). Pour les types d'échantillons et les besoins autres que le profilage immunitaire des biopsies, Precision propose également une suite complète d'applications génomiques.

Nos services sont conçus pour répondre aux objectifs de votre projet, que ce soit par le biais de panels préexistants ou d'un essai personnalisé.

Séquenceurs NGS Illumina et Thermo Fisher

Nous utilisons à la fois Illumina et Thermo Fisher pour le séquençage next-gen. Les études RNA-seq sont également réalisées avec Illumina, y compris le panel AmpliSeq for Illumina Immune Response Panel.

NanoString nCounter®

Pour les études quantitatives d'expression génique hautement multiplexées, nous utilisons la plateforme NanoString nCounter®. Ce système détecte directement l'ARN, évitant ainsi le risque de biais introduit par les approches basées sur l'amplification par PCR.

Nous pouvons utiliser les panels d'immuno-oncologie et d'immunologie de NanoString ou créer un panel personnalisé pour votre étude.

Système de PCR en temps réel QuantStudio™ 12K flex

Pour un profilage rentable et multiplexé de l'expression génique de nombreux échantillons en parallèle, nous proposons des analyses à l'aide de plaques OpenArray sur la plateforme qPCR QuantStudio 12K Flex.

QX200™ ddPCR™

La PCR numérique est appropriée lorsque des analyses très sensibles et une quantification absolue sont nécessaires. Precision utilise le système ddPCR QX200 de Bio-Rad.

Agena MassARRAY

Solution à haut débit pour le génotypage, la détection des mutations somatiques, l'analyse de la méthylation de l'ADN et l'analyse de la régulation de l'expression des gènes. Precision for Medicine propose les tests MassARRAY® soit en tant que service individuel, soit dans le cadre d'une offre globale de développement thérapeutique, qui comprend des tests de biomarqueurs et des essais cliniques.

Precision fournit également des échantillons biologiques prêts pour la recherche

En plus des services, Precision dispose d'échantillons biologiques prêts pour l'analyse génomique, ainsi que d'échantillons pré-caractérisés par NGS.

Tissus FFPE Explorer Biospécimens caractérisés par NGS Explorer Micropuces tissulaires Explorer

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