Skip to content
Precision for Medicine
iStock-1421515036 (2)

Profilage de l'expression génétique des biopsies

Le profilage de l'expression génétique des biopsies tumorales et des biopsies liquides peut fournir des informations sur l'inflammation et l'état immunitaire général.
Le profilage des biopsies par l'expression des gènes peut servir d'outil pour le dépistage des tumeurs susceptibles de répondre à des traitements tels que les inhibiteurs de points de contrôle, pour l'évaluation de l'efficacité thérapeutique, pour la mise en évidence du mécanisme d'action et pour toute une série d'autres applications.

Profilage complet et quantitatif de l'expression des gènes

Precision propose des tests de profilage de l'expression génique et de transcriptomique pour surveiller l'état immunitaire à l'aide des technologies de séquençage de nouvelle génération (NGS), NanoString, qPCR et Droplet Digital™ PCR (ddPCR). Pour les types d'échantillons et les besoins autres que le profilage immunitaire des biopsies, Precision propose également une suite complète d'applications génomiques.

Nos services sont conçus pour répondre aux objectifs de votre projet, que ce soit par le biais de panels préexistants ou d'un essai personnalisé.

Séquenceurs NGS Illumina et Thermo Fisher

Nous utilisons à la fois Illumina et Thermo Fisher pour le séquençage next-gen. Les études RNA-seq sont également réalisées avec Illumina, y compris le panel AmpliSeq for Illumina Immune Response Panel.

NanoString nCounter®

Pour les études quantitatives d'expression génique hautement multiplexées, nous utilisons la plateforme NanoString nCounter®. Ce système détecte directement l'ARN, évitant ainsi le risque de biais introduit par les approches basées sur l'amplification par PCR.

Nous pouvons utiliser les panels d'immuno-oncologie et d'immunologie de NanoString ou créer un panel personnalisé pour votre étude.

Système de PCR en temps réel QuantStudio™ 12K flex

Pour un profilage rentable et multiplexé de l'expression génique de nombreux échantillons en parallèle, nous proposons des analyses à l'aide de plaques OpenArray sur la plateforme qPCR QuantStudio 12K Flex.

QX200™ ddPCR™

La PCR numérique est appropriée lorsque des analyses très sensibles et une quantification absolue sont nécessaires. Precision utilise le système ddPCR QX200 de Bio-Rad.

Agena MassARRAY

Solution à haut débit pour le génotypage, la détection des mutations somatiques, l'analyse de la méthylation de l'ADN et l'analyse de la régulation de l'expression des gènes. Precision for Medicine propose les tests MassARRAY® soit en tant que service individuel, soit dans le cadre d'une offre globale de développement thérapeutique, qui comprend des tests de biomarqueurs et des essais cliniques.

Precision fournit également des échantillons biologiques prêts pour la recherche

En plus des services, Precision dispose d'échantillons biologiques prêts pour l'analyse génomique, ainsi que d'échantillons pré-caractérisés par NGS.

Explorer le blog de Precision

Lisez notre blog pour en savoir plus et découvrir les travaux soutenus par Precision.

Read: What the EMA–FDA AI Principles Really Mean for Clinical Development & Regulatory Affairs What the EMA–FDA AI Principles Really Mean for Clinical Development & Regulatory Affairs

Clinical Trials - Regulatory

What the EMA–FDA AI Principles Really Mean for Clinical Development & Regulatory Affairs

|
    has third author: false, (SizeLimitingPyMap: {main={hs_id=195804116748, hs_child_table_id=0, hs_updated_at=1764696930757, hs_published_at=1772549698856, description=John is an experienced regulatory affairs consultant with more than 15 years of professional experience in drug development. He brings a proven track record in providing regulatory strategy, regulatory document development and review, and liaising with regulatory authorities., avatar=Image{width=276,height=290,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/PfM%20Website/Headshots/Headshots%20no%20background/John%20McIntyre.png',altText='John McIntyre',fileId=201584594055}, lastname=McIntyre, PhD, hs_initial_published_at=1757516163742, hs_created_by_user_id=26433386, hs_created_at=1757515873736, hs_is_edited=false, hs_deleted_at=0, name=John, job=Senior Director, Regulatory Strategy, slug=john-mcintyre, hs_updated_by_user_id=26433386}, second={hs_id=195821592097, hs_child_table_id=0, hs_updated_at=1757598947835, hs_published_at=1772549698856, description=An expert in hematology and oncology and a veteran of the FDA with almost nine years of experience, culminating as a Deputy Director for the Division of Hematologic Malignancies 2. Possesses a profound understanding of regulatory strategy, particularly in the development of CAR-T cell therapies, bispecifics and T-cell engagers. Spearheaded initiatives to develop novel endpoints in blood cancer such as minimal residual disease (MRD) in lymphoma and chronic lymphocytic leukemia (CLL.), avatar=Image{width=276,height=290,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/PfM%20Website/Headshots/Headshots%20no%20background/Nicholas%20Richardson.png',altText='Nicholas Richardson',fileId=195817841672}, linkedin=https://www.linkedin.com/in/nicholas-richardson-do-mph-049784113/, team=[{id=163080551773, name='Clinical Solutions Leadership'}], lastname=Richardson, DO, MPH, hs_initial_published_at=1757528527317, hs_created_by_user_id=51739740, hs_created_at=1757528274871, hs_is_edited=false, hs_deleted_at=0, name=Nicholas, job=Vice President, Clinical Development, slug=nicholas-richardson-clinical-solutions, hs_updated_by_user_id=26433386}, third={hs_id=178046423372, hs_child_table_id=0, hs_updated_at=1754641388766, hs_published_at=1772549698856, description=Rosamund (Roz) Round is a seasoned expert in patient engagement and innovation bringing over 20 years of experience. She is focused on listening to and learning from patients and care partners to understand how to better improve trial access and experience. Roz successfully built and led decentralized clinical trials service through the pandemic and is now addressing the implementation of AI across various aspects of clinical research. She has a strong focus on diversity, equity, and inclusion (DEI) to drive health equity in clinical research. Roz holds an MSc in Health Psychology, studied Psychology and Immunology at Harvard University, and is a recognized thought leader with an extensive portfolio of publications, conference presentations, webinars, and vlogs., avatar=Image{width=287,height=287,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/PfM%20Website/PfMxMarkentive/authors/Round-Rosamund.png',altText='Round-Rosamund',fileId=194123714174}, lastname=Round, hs_initial_published_at=1725972637852, hs_created_by_user_id=51739740, hs_created_at=1725972446462, hs_is_edited=false, hs_deleted_at=0, name=Rosamund, job=Vice President, PAtient Engagement & Innovation, slug=rosamund-round, hs_updated_by_user_id=26433386}})
  • John M. avatar Nicholas R. avatar Rosamund R. avatar
  • John M.

    Nicholas R.

    Rosamund R.

Découvrir
Read: Case Study: Scaling a First Line NSCLC Trial in a Hesitant Market Case Study: Scaling a First Line NSCLC Trial in a Hesitant Market

Oncology

Case Study: Scaling a First Line NSCLC Trial in a Hesitant Market

|
    has not third author: true, (SizeLimitingPyMap: {main={hs_id=208638641305, hs_child_table_id=0, hs_updated_at=1772549693775, hs_published_at=1772549698856, description=Lisa is a Director, Project Management who has been with Precision since Jan 2019. Lisa has over 18 years of clinical research experience, with a proven track record in leading cross-functional teams across programs of studies. Lisa is a collaborative communicator capable of cultivating key relationships focused on customer satisfaction. In 2018, Lisa was granted the CEO Excellence Award for exceptional project management., avatar=Image{width=378,height=339,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/Lisa%20Lopez_Headshot.jpg',altText='Lisa Lopez_Headshot',fileId=208044988231}, lastname=Lopez, hs_initial_published_at=1772549698856, hs_created_by_user_id=26433386, hs_created_at=1772549635830, hs_is_edited=false, hs_deleted_at=0, name=Lisa, job=Director, Project Management, slug=lisa-lopez, hs_updated_by_user_id=26433386}, second={hs_id=208600974006, hs_child_table_id=0, hs_updated_at=1772549671531, hs_published_at=1772549698856, description=Adrien (Ash) Mtibaa, MD is a clinical research leader with 10+ years of experience in global clinical trials and deep expertise in Site Start‑Up (SSU). Currently Manager, Site Start‑Up at Precision for Medicine, he leads and mentors global SSU teams with a strong focus on process improvement, SSU strategy, leadership influence, and line management. A trained Medical Doctor, Adrien brings a pragmatic, results‑driven approach to driving activation readiness, operational excellence, and cross‑functional alignment across multi‑regional studies., avatar=Image{width=800,height=800,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/Adrien%20Mtibaa%2c%20MD.jpg',altText='Adrien Mtibaa, MD',fileId=208642032927}, lastname=Mtibaa, MD, hs_initial_published_at=1772549611983, hs_created_by_user_id=26433386, hs_created_at=1772488816847, hs_is_edited=false, hs_deleted_at=0, name=Adrien, job=Manager, Site Start Up, slug=adrien-mtibaa, hs_updated_by_user_id=26433386}, third={}})
  • Lisa L. avatar

    Lisa L.

  • Adrien M. avatar

    Adrien M.

Découvrir
Read: Developing a Comprehensive Strategy for Implementing AI & Multi-Omics for Translational Research Developing a Comprehensive Strategy for Implementing AI & Multi-Omics for Translational Research

Translational Research

Developing a Comprehensive Strategy for Implementing AI & Multi-Omics for Translational Research

|
    has not third author: true, (SizeLimitingPyMap: {main={hs_id=199448088864, hs_child_table_id=0, hs_updated_at=1762810484868, hs_published_at=1772549698856, avatar=Image{width=1200,height=1200,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/Kaylee%20Mueller.png',altText='Kaylee Mueller',fileId=199456336149}, lastname=Mueller, hs_initial_published_at=1762810487482, hs_created_by_user_id=26433386, hs_created_at=1762810467146, hs_is_edited=false, hs_deleted_at=0, name=Kaylee, slug=kaylee-mueller, hs_updated_by_user_id=26433386}, second={}, third={}})
  • Kaylee Mueller avatar

    Kaylee Mueller

Découvrir