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Precision for Medicine
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Profilage de l'expression génétique des biopsies

Le profilage de l'expression génétique des biopsies tumorales et des biopsies liquides peut fournir des informations sur l'inflammation et l'état immunitaire général.
Le profilage des biopsies par l'expression des gènes peut servir d'outil pour le dépistage des tumeurs susceptibles de répondre à des traitements tels que les inhibiteurs de points de contrôle, pour l'évaluation de l'efficacité thérapeutique, pour la mise en évidence du mécanisme d'action et pour toute une série d'autres applications.

Profilage complet et quantitatif de l'expression des gènes

Precision propose des tests de profilage de l'expression génique et de transcriptomique pour surveiller l'état immunitaire à l'aide des technologies de séquençage de nouvelle génération (NGS), NanoString, qPCR et Droplet Digital™ PCR (ddPCR). Pour les types d'échantillons et les besoins autres que le profilage immunitaire des biopsies, Precision propose également une suite complète d'applications génomiques.

Nos services sont conçus pour répondre aux objectifs de votre projet, que ce soit par le biais de panels préexistants ou d'un essai personnalisé.

Séquenceurs NGS Illumina et Thermo Fisher

Nous utilisons à la fois Illumina et Thermo Fisher pour le séquençage next-gen. Les études RNA-seq sont également réalisées avec Illumina, y compris le panel AmpliSeq for Illumina Immune Response Panel.

NanoString nCounter®

Pour les études quantitatives d'expression génique hautement multiplexées, nous utilisons la plateforme NanoString nCounter®. Ce système détecte directement l'ARN, évitant ainsi le risque de biais introduit par les approches basées sur l'amplification par PCR.

Nous pouvons utiliser les panels d'immuno-oncologie et d'immunologie de NanoString ou créer un panel personnalisé pour votre étude.

Système de PCR en temps réel QuantStudio™ 12K flex

Pour un profilage rentable et multiplexé de l'expression génique de nombreux échantillons en parallèle, nous proposons des analyses à l'aide de plaques OpenArray sur la plateforme qPCR QuantStudio 12K Flex.

QX200™ ddPCR™

La PCR numérique est appropriée lorsque des analyses très sensibles et une quantification absolue sont nécessaires. Precision utilise le système ddPCR QX200 de Bio-Rad.

Agena MassARRAY

Solution à haut débit pour le génotypage, la détection des mutations somatiques, l'analyse de la méthylation de l'ADN et l'analyse de la régulation de l'expression des gènes. Precision for Medicine propose les tests MassARRAY® soit en tant que service individuel, soit dans le cadre d'une offre globale de développement thérapeutique, qui comprend des tests de biomarqueurs et des essais cliniques.

Precision fournit également des échantillons biologiques prêts pour la recherche

En plus des services, Precision dispose d'échantillons biologiques prêts pour l'analyse génomique, ainsi que d'échantillons pré-caractérisés par NGS.

Explorer le blog de Precision

Lisez notre blog pour en savoir plus et découvrir les travaux soutenus par Precision.

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Clinical Trials - Early Phase Research - Autoimmune

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    has third author: false, (SizeLimitingPyMap: {main={hs_id=214928090133, hs_child_table_id=0, hs_updated_at=1781285625399, hs_published_at=1784230314171, description=Deborah Spencer is a Senior Director of Project Management at Precision for Medicine with over 25 years of experience in clinical research. She specialises in leading global clinical trials across multiple phases, with deep expertise in complex study delivery. Deborah provides strategic oversight of programmes, leads high-performing teams, and partners closely with sponsors to ensure successful execution and regulatory readiness., avatar=Image{width=1200,height=1200,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/Deborah%20Spencer.jpg',altText='Deborah Spencer',fileId=214838919278}, lastname=Spencer, hs_initial_published_at=1781285742914, hs_created_by_user_id=26433386, hs_created_at=1781285562019, hs_is_edited=false, hs_deleted_at=0, name=Deborah, job=Senior Director, Project Management, slug=deborah-spencer, hs_updated_by_user_id=51739740}, second={hs_id=214928170660, hs_child_table_id=0, hs_updated_at=1781285676367, hs_published_at=1784230314171, description=Anthea Gates is a Project Director with approximately 30 years of drug development and medical device industry expertise across all phases, over a variety of indications including breast, lung cancer, solid tumors and lymphoma, cutaneous T-cell lymphoma, malignant melanoma, squamous cell carcinoma, rare haematologic disease, autoimmune rheumatology, osteoarthritis, ocular burns, liver cirrhosis, myopia and pre-eclampsia. Committed to delivering quality and passionate about building positive relationships with clients and study teams to promote cohesive business practices and ensure the successful management of projects from start to finish. Anthea holds a proven track record in effective leadership of cross-functional teams across programs of studies, to the accomplishment of operational excellence., avatar=Image{width=372,height=546,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/profile.jpg',altText='profile',fileId=214846873938}, lastname=Gates, hs_initial_published_at=1781285742914, hs_created_by_user_id=26433386, hs_created_at=1781285639221, hs_is_edited=false, hs_deleted_at=0, name=Anthea, job=Project Director, slug=anthea-gates, hs_updated_by_user_id=51739740}, third={hs_id=214928090141, hs_child_table_id=0, hs_updated_at=1781285738567, hs_published_at=1784230314171, description=Claire Delaville is a Senior Project Manager at Precision for Medicine. She brings 18 years of experience across preclinical and clinical research, including more than a decade leading Phase I to IV studies in oncology, rare diseases, and immunology, with direct experience in first-in-human and multicenter oncology trials. Claire is responsible for maintaining study quality through inspection readiness, corrective action planning, and proactive risk mitigation. She also oversees study budgets and vendor performance to support coordinated delivery across functions, drawing on a scientific foundation that includes a PhD in Neurosciences and Neuropharmacology. Based in Paris, France, Claire aligns scientific insight with operational execution to support successful trial outcomes., avatar=Image{width=1200,height=1200,url='https://5014803.fs1.hubspotusercontent-na1.net/hubfs/5014803/Claire%20Delaville.jpg',altText='Claire Delaville',fileId=214838927033}, lastname=Delaville, hs_initial_published_at=1781285742914, hs_created_by_user_id=26433386, hs_created_at=1781285678112, hs_is_edited=false, hs_deleted_at=0, name=Claire, job=Senior Project Manager, slug=claire-delaville, hs_updated_by_user_id=51739740}})
  • Deborah S. avatar Anthea G. avatar Claire D. avatar
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