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Meso Scale Discovery (MSD) Assays

Profile cytokines, detect biomarkers, or perform ADA & PK studies at any clinical phase with MSD

Understanding the abundance of a specific protein or set of proteins is one of the most basic measurements needed in pre-clinical and clinical research. The Meso Scale Discovery (MSD) platform can analyze these with consistency, high-throughput, and low sample input.

Precision can help you develop and validate custom MSD panels, or run fully validated kits.

MSD capabilities
Regulatory expertise
MSD assay formats
Validated MSD kits
Instruments
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What is Meso Scale Discovery?

The MSD technology is a method that works on the same principle as ELISA assays but relies on eletrochemiluminescent (ECL) signals as a detection method.

This gives MSD platform several advantages over traditional ELISA:

  • Flexible multiplexing: up to 10 analytes
  • Wider dynamic range
  • Higher sensitivity
  • Lower sample volume
  • Less matrix interference
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How Precision uses MSD to empower your research

For non-clinical and clinical studies, perform:

  • Biomarker and cytokine profiling
  • Pharmacokinetic (PK) and anti-drug antibody (ADA) assays
  • Or develop PK and ADA assays de novo by conjugating capture and detection antibodies with biotin or Sulfo-tag

With our MSD expertise, navigate and plan for:

  • Challenges of multiplexing, reagent procurement, data tabulation, matrix interference, and bridging of reagents

Strategize with us to:

  • Choose which biomarkers to target, ideal platform, and level of regulation
  • Develop methods or optimize existing protocols for your specific requirements to accelerate your clinical program

Precision employs a platform-agnostic approach in working with you to choose the best solution, whether that be MSD, ELISA, or another format.

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Support your assays with comprehensive regulatory expertise

  • Assay development or transfer, qualification, validation, and non-clinical and clinical sample testing
  • Pre-built, validated MSD assay plates
  • Support pre-clinical through phase 3 and post marketing studies
  • GCP/GLP/CLIA/CDx regulated assays

Assays to address any of your endpoints

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Matched antibody sets for your own single or multiplex assay

Flexible, customized multiplex assays

Ready-to-use single and multiplex assays kits

Validated single and multiplex assay kits

Ultrasensitive single plex and multiplex assay kits

Provides an expanding menu of emerging biomarkers with MSD MULTI-ARRAY performance

Easily creates customized multiplex panels. Use MSD reagents or bring your own

Analyzes protein levels from many sample types with a single assay. Improved analytical performance

Provides confidence and reliability. Analytically validated with guaranteed performance specifications

Measures proteins that are otherwise unmeasurable.

Explore some validated kits and the markers they measure

V-PLEX Cytokine Panel 1 Human Kit

GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A

V-PLEX Proinflammatory Panel 1 Human Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α
V-PLEX Chemokine Panel 1 Human Kit

MCP-1, MCP-4, Eotaxin, Eotaxin-3, IP-10, MDC, TARC, MIP-1α, MIP-1β, IL-8 (HA), IL-8

 

Precision's available MSD instruments

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Meso Sector S 600MM

High speed, low-noise CCD camera; high sensitivity, wide dynamic range, rapid read times

Meso Quickplex SQ 120MM

Multi-array technology combines high sensitivity, excellent reproducibility and wide dynamic range. 

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Combine your biomarker and clinical trial data

To help researchers understand and interpret biomarker assay data in the context of other assays as well as the clinical trial data, Precision provides the option to manage and analyze assay data using our proprietary QuartzBio Translational Informatics platform.

Learn more about the computational biology, informatics, and sample inventory management capabilities of QuartzBio.
Learn more about QuartzBio

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