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Immune Monitoring by Epiontis ID®

Precision’s Epiontis ID® technology is a robust, adaptable, and cost-effective solution for immune cell profiling
Run on an automated platform for consistent, unbiased results, Epiontis ID® phenotypes cells using cell-type specific epigenetic markers. With minimal sample processing, it simplifies global trial logistics and minimizes sample to sample or site to site variability, enabling comparison across studies, locations, and timepoints. This makes it an ideal choice for immune monitoring in both early stage and advanced clinical trials.

Epiontis ID® is unique in its approach to clinical immune monitoring

Discover the distinct benefits and advantages of Epiontis ID®’s immune monitoring platform:
  • Simplified Logistics
  • Wide Range of Sample Matrices
  • Proven Clinical Utility
  • Precise and Reproducible Results
  • Easy Logistics,
    Reliable Results

    Epiontis ID® is versatile and compatible with diverse sample types, with minimal sample processing required. Samples can be transported ambient within a 3-day window or batch-shipped in a frozen state. All assays are uniformly performed in facilities accredited with ISO 17025 and compliant with GCP/ICH guidelines.
    • Choose from >35 fully validated assays

    • Collect sample at clinical site without processing

    • Ship ambient or frozen in batches

    • Samples arrive at central lab, measured with quick turnaround

  • Wide Range of Sample Matrices

    Monitor immune cells in whole blood, tissue, and many other biological samples:
    • Dried blood spots (DBS)
    • Peripheral blood mononuclear cells (PBMC)
    • In vitro expanded cells
    • Whole blood (heparin, EDTA, Paxgene vials)
    • Clotted blood from serum tubes
    • Formalin-fixed paraffin-embedded (FFPE) samples
    • Fixed blood (lysed erythrocytes)
    • Fresh-frozen tissue
    • Tissue stored in RNAlater
    • Urine
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  • Proven Clinical Utility

    Epiontis has been used routinely in clinical studies with over 100,000 clinical samples analyzed, including as a secondary outcome measure.

    This has produced data routinely included in peer-reviewed publications and poster presentations at conferences such as AACR, ASCO, and AAI.

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  • Precise and Reproducible Results

    Excellent comparability of results within and across studies allows for highly flexible batch selection, adding additional cell types and samples to a study as needed.
    • Fully automated process and use of references and calibrators ensure highly reliable results
    • Long-term monitoring shows absence of shifts or drifts
    • This allows flexible batch selection: Measure a subset first, then extend number of subjects or assays
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Epiontis ID® explained

Combining the Power of Epigenetics and the Consistency of qPCR, Epiontis ID® harnesses the unique methylation patterns specific to distinct cell types and uses a customized process and qPCR primers to amplify only those DNA regions that are demethylated in the cell type of interest. 

The quantitative nature of qPCR then allows for a precise count of the number of cells of interest in any sample. The uniformity and objectivity of qPCR results yield highly reproducible data that can be compared within and across various studies.

epiontis id process

See how Epiontis ID® technology works

Within our suite of immune monitoring services, Epiontis ID® proprietary technology stands out by offering an epigenetic approach to cell profiling. Watch to learn how.

Epiontis ID® :
Use Cases Across Diverse Therapeutic Areas

Epiontis ID® has many uses across therapeutic areas; this is a collection of the myriad examples of how Epiontis ID® can be used in advanced research.


Epiontis ID: Use Cases Across Diverse Therapeutic Areas

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Epiontis ID: Use Cases Across Diverse Therapeutic Areas

All of Epiontis ID®’s assays are fully validated and can be rapidly set up to run

Download the full list of validated panels

The scientific team behind Epiontis ID® continuously adds new available cell types, often in response to specific client requests or needs. We do more than just create a customized assay; we provide a comprehensive biomarker strategy that incorporates Epiontis ID® and various other technologies to help achieve your clinical development objectives. Currently, there are over 35 validated assays available for Epiontis ID®, with additional cell types added regularly. Study sponsors can select and combine any of the available cell types into a panel for analysis.

T LymphocytesOther Immune CellsExhaustion / Activation / Migration MarkersOther Cells types (Fibrocytes)
  • CD3 T cells
  • CD4 T cells
  • CD8 T cells
  • Regulatory T cells
  • Th17 cells
  • TFH cells
  • Gamma Delta T cells
  • GATA3 positive cells
  • CD4 memory t cells
  • CD8 naïve T cells
  • B cells
  • NK cells
  • Neutrophils
  • Eosinophils
  • Basophils
  • Monocytes
  • NC monocytes
  • Monocytic MDSC
  • Plasmacytoid DC
  • Naïve B cells
  • Memory B cells
  • IgM positive B cells
  • PD1+ cells
  • TIGIT+ cells
  • CTLA4+ cells
  • LAG3+ cells
  • CXCR3+ cells
  • Granulysin+ cells
  • CCR7+ cells
  • IL6R+ cells
  • CCR6+ cells
  • CRTH2+ cells
  • S1PR1+ cells
  • S1PR5+ cells
  • Integrin alpha 4+ cells
  • Col1A1+ cells
  • PDGFRB+ cells