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Next-Generation Sequencing (NGS) Services
Precision supports pre-clinical and clinical studies with NGS services using Illumina and Thermo Fisher Scientific sequencing platforms, enabling discovery of single nucleotide variants (SNVs), indels (insertions/deletions), gene translocations, rearrangements, copy number alterations, and changes in mRNA or microRNA expression levels. We can perform assays according to CLIA as needed.
Detailed insights using NGS
Gain a comprehensive understanding of the unique genomic and transcriptomic makeup of your pre-clinical or clinical samples.
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DNA
- Whole genome sequencing (WGS)
- Whole exome sequencing (WES)
- Tumor mutational burden (TMB) estimation
- Microsatellite instability (MSI)Custom assays
- Targeted panels
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- TruSight Oncology 500
- Oncomine Precision Assay
- Oncomine Myeloid Assay
- Oncomine Comprehensive Assay
- Oncomine TCR Beta-LR Assay
- Oncomine BRCA Assay
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RNA
- Whole transcriptome RNA-seq
- miRNA and other small RNA sequencing
- Single-cell sequencing
- Characterization of differentially expressed splice site variants
- Targeted RNA-seq panels
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Combine with liquid biopsy to deliver robust data from less sample
To help researchers derive maximum biomarker data even from limited samples, Precision can leverage multiple technologies on the same sample. For example, ApoStream enables enrichment of circulating tumor cells (CTCs) which can then be sequenced using NGS for powerful genomics profiling insight into liquid biopsies.
Next-gen sequencing workflow
Sample preparation
Support a broad range of sample types, from cell lines to fresh tissue, formalin-fixed paraffin-embedded (FFPE) samples, and blood
DNA/RNA Extraction
Precision provides both automated and manual extraction kits and platforms for a custom approach to your project.
Library prep
Automated liquid handling systems help laboratories obtain and maintain consistent results while driving efficiency
Sequence
Use a range of target panels (e.g. RNA-seq, TSO500) to interrogate biomarkers important in your trials
Analyze and discover
Integrate NGS tools of choice or your own data pipelines to ensure smooth data analysis, so you can spend more time doing research and less time configuring workflows
Conduct multi-site trials globally
Our NGS services support pre-clinical and clinical research, including multi-site studies, conducted anywhere in the world.
Consult with Precision for a personalized plan
Precision’s specialty lab scientists take a collaborative and consultative approach to projects and can provide recommendations on biomarker assay strategies and implementation, such as choosing the best genomics platform for your study.
Services can be provided individually or as part of a comprehensive therapeutic development package including biomarker assays and clinical trials.
Build on your insights with complementary platforms
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Explore
NanoString
Panels that enable the simultaneous analysis of up to 800 genes; ideal for projects where highly multiplexed analysis is needed, such as oncology and autoimmune therapeutic development -
Explore
ddPCR
Advanced ddPCR applications from preclinical to clinical assays including gene therapy viral shedding and CAR-T biodistribution -
Explore
FISH/ISH
Development of multiplex FISH/ISH assays to detect abnormalities in a range of tissues, including hematological and solid organ tumors
