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Next-Generation Sequencing (NGS) Services

Uncover a highly detailed view of genomic events occurring within a sample

Precision supports pre-clinical and clinical studies with NGS services using Illumina and Thermo Fisher Scientific sequencing platforms, enabling discovery of single nucleotide variants (SNVs), indels (insertions/deletions), gene translocations, rearrangements, copy number alterations, and changes in mRNA or microRNA expression levels. We can perform assays according to CLIA as needed.

  • Detailed insights using NGS

    Gain a comprehensive understanding of the unique genomic and transcriptomic makeup of your pre-clinical or clinical samples.

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    DNA

    • Whole genome sequencing (WGS)
    • Whole exome sequencing (WES) 
    • Tumor mutational burden (TMB) estimation
    • Microsatellite instability (MSI)Custom assays
    • Targeted panels
      • TruSight Oncology 500
      • Oncomine Precision Assay 
      • Oncomine Myeloid Assay
      • Oncomine Comprehensive Assay
      • Oncomine TCR Beta-LR Assay
      • Oncomine BRCA Assay
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    RNA

    • Whole transcriptome RNA-seq
    • miRNA and other small RNA sequencing
    • Single-cell sequencing
    • Characterization of differentially expressed splice site variants
    • Targeted RNA-seq panels

Precision offers a range of available NGS Instrumentation

We utilize a platform-agnostic approach to provide best-fit solutions for your projects.

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NextSeq 550 Dx
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NovaSeq 6000
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iSeq 100

Thermo Fisher Scientific
 Ion Torrent Genexus Integrated Sequencer 
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Combine with liquid biopsy to deliver robust data from less sample

To help researchers derive maximum biomarker data even from limited samples, Precision can leverage multiple technologies on the same sample. For example, ApoStream enables enrichment of circulating tumor cells (CTCs) which can then be sequenced using NGS for powerful genomics profiling insight into liquid biopsies.

Next-gen sequencing workflow

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Sample preparation

Support a broad range of sample types, from cell lines to fresh tissue, formalin-fixed paraffin-embedded (FFPE) samples, and blood

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DNA/RNA Extraction

Precision provides both automated  and manual extraction kits and platforms for a custom approach to your project.

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Library prep

Automated liquid handling systems help laboratories obtain and maintain consistent results while driving efficiency

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Sequence

Use a range of target panels (e.g. RNA-seq, TSO500) to interrogate biomarkers important in your trials

Analyze and discover

Integrate NGS tools of choice or your own data pipelines to ensure smooth data analysis, so you can spend more time doing research and less time configuring workflows

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Conduct multi-site trials globally

Our NGS services support pre-clinical and clinical research, including multi-site studies, conducted anywhere in the world.

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Consult with Precision for a personalized plan

Precision’s specialty lab scientists take a collaborative and consultative approach to projects and can provide recommendations on biomarker assay strategies and implementation, such as choosing the best genomics platform for your study.

Services can be provided individually or as part of a comprehensive therapeutic development package including biomarker assays and clinical trials.

Build on your insights with complementary platforms

  • NanoString

    Panels that enable the simultaneous analysis of up to 800 genes; ideal for projects where highly multiplexed analysis is needed, such as oncology and autoimmune therapeutic development
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  • ddPCR

    Advanced ddPCR applications from preclinical to clinical assays including gene therapy viral shedding and CAR-T biodistribution
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  • FISH/ISH

    Development of multiplex FISH/ISH assays to detect abnormalities in a range of tissues, including hematological and solid organ tumors
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